Pharmacology of Intracranial Pressure Management

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Course Credit: 1 hour

This Capsule on the Pharmacology of Intracranial Pressure Management delves into the differences between agents to treat cerebral edema, goal setting for blood pressure in the setting of intracranial hemorrhage, as well as the various antihypertensive agents used to achieve those goals.

Learning Objectives

  1. Evaluate different hyperosmolar agents for reducing intracranial pressure
  2. Select goal systolic blood pressure targets based on type of neurologic injury
  3. Design an antihypertensive regimen incorporating patient specific factors to achieve recommended blood pressure goals

Intracranial Pressure – Course Contributors

Jamie M. Rosini, PharmD, MS, BCPS, BCCCP, DABATEmergency Medicine Pharmacist, Christiana Care Health System@jrozzini
Ashley N. Martinelli, PharmD, BCCCPEmergency Medicine Pharmacist, University of Maryland Medical Center@RxMartinelli
PharmD Reviewer: Glenn Oettinger, PharmDThomas Jefferson University Hospital@glennoettinger
Copy Editor: Emily Wiener, PharmDEmergency Medicine Pharmacist, Baltimore Washington Medical Center@PharmdEMily
Associate Editor: Nadia Awad, PharmD, BCPSEmergency Medicine Pharmacist, Robert Wood Johnson University Hospital@Nadia_EMPharmD
Lead Editor: Bryan Hayes, PharmD, FAACT, FASHPClinical Pharmacy Manager, Massachusetts General Hospital@PharmERToxGuy

2 thoughts on “Pharmacology of Intracranial Pressure Management”

    1. Michelle Lin, MD

      Hi Mary: I got this response from Bryan Hayes:

      “HTS 3% can be administered as a bolus. HTS 23.4% is usually administered over 1-20minutes. We use a syringe pump for it. Mannitol¬†is administered over 20-30 minutes. Anything faster causes hypotension.”

      Bryan D. Hayes, PharmD, DABAT, FAACT, FASHP
      Clinical Pharmacy Manager – Emergency Medicine, Pediatrics, & Overnight Services
      Assistant Professor – Department of EM, Division of Toxicology
      Immediate Past-President, American Board of Applied Toxicology (ABAT)
      Massachusetts General Hospital | Harvard Medical School

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